Essentials of Biostatistics in Public Health 4th Edition Sullivan Solution Manual
Solution Manual for Essentials of Biostatistics in Public Health 4th Edition by Lisa M. Sullivan, ISBN-10: 1284296253, ISBN-13: 9781284296259, ISBN-10: 1284288730, ISBN-13: 9781284288735
TABLE OF CONTENTS
Chapter 1 Introduction
Chapter 2 Study Designs
Chapter 3 Quantifying the Extent of Disease
Chapter 4 Summarizing Data Collected in the Sample
Chapter 5 The Role of Probability
Chapter 6 Confidence Interval Estimates
Chapter 7 Hypothesis Testing Procedures
Chapter 8 Power and Sample Size Determination
Chapter 9 Multivariable Methods
Chapter 10 Nonparametric Tests
Chapter 11 Survival Analysis
Chapter 12 Data Visualization
Chapter 13 Careers in Biostatistics
CHAPTER 2
1. An investigator wants to assess whether smoking is a risk factor for pancreatic cancer. Electronic medical records at a local hospital will be used to identify 50 patients with pancreatic cancer. One hundred patients who are similar but free of pancreatic cancer will also be selected. Each participant’s medical record will be analyzed for smoking history. Identify the type of study proposed and indicate its specific strengths and weaknesses.
Answer:
The study is a case-control study. Patients with pancreatic cancer are considered cases and patients free of cancer are controls. Strengths of the design include cost and time efficiency to identify a sufficient number of cases for analysis. Weaknesses include generalizability (study participants were all patients at one hospital) and ascertainment of exposure status (smoking). Exposure data will be collected from medical records, which may not have smoking recorded accurately.
2. What is the most likely source of bias in the study described in Problem 1?
Answer:
The most likely source of bias is misclassification bias, particularly with regard to classification of smoking status (exposure) because smoking information will be collected from the medical record.
